| 03 Dic 2020 | CD Tenerife SAD | 1 - 2 | CE Sabadell FC SAD | |
| 03 Dic 2020 | Real Sporting de Gijón SAD | 0 - 0 | Albacete Balompié SAD | |
| 03 Dic 2020 | Real Oviedo SAD | 1 - 1 | AD Alcorcón SAD | |
| 02 Dic 2020 | CD Lugo SAD | 1 - 1 | UD Las Palmas SAD | |
| 02 Dic 2020 | CD Leganés SAD | 1 - 0 | Rayo Vallecano de Madrid SAD | |
| 02 Dic 2020 | UD Logroñés SAD | 1 - 2 | SD Ponferradina SAD | |
| 01 Dic 2020 | CF Fuenlabrada SAD | 0 - 2 | Málaga CF SAD | |
| 01 Dic 2020 | Girona FC SAD | 1 - 0 | CD Mirandés SAD | |
| 02 Dic 2020 | CD Castellón SAD | 1 - 0 | Real Zaragoza SAD | |
| 02 Dic 2020 | FC Cartagena SAD | 1 - 3 | RCD Espanyol de Barcelona SAD | |
| 03 Dic 2020 | UD Almería SAD | 0 - 1 | RCD Mallorca SAD | |
